Cerebrospinal fluid (CSF) biomarkers may be used to identify and monitor pathological processes in the central nervous system. CSF biomarkers in Alzheimer’s disease (AD) include β-amyloid 42 (Aβ42), total-tau (T-tau) and phosphorylated-tau (P-tau), reflecting brain amyloid, axonal and tangle pathology, respectively. This dissertation aims at defining and validating CSF biomarkers for amyloid an...

Acetyl-CoA provision to the synaptoplasmic compartment of cholinergic nerve terminals plays a regulatory role in the synthesis of acetylcholine. The disturbances in glucose utilization and in decarboxylation of the end product of its metabolism pyruvate, are considered to be significant factors causing cholinergic deficits in several diseases of the central nervous system. In this article we re...

Background: With increasing proportion of geriatric population, late-life co-morbidities including dementias, heart disease, arthritis and cancers are also steadily. Cognitive impairment, mainly affecting the is condition when a person has trouble remembering, learning new things, concentrating or making decisions that affect their everyday life, often considered precursor to more serious disea...

We evaluated the role of several proteins that are likely to be involved in alzheimers disease (AD) and type 2 diabetes mellitus (T2DM). By employing multiple sequence alignment using Clustalw tool, we have constructed a phylogenetic tree based on the functional protein sequences extracted form NCBI. The phylogram was constructed using neighbor joining algorithm. Our bioinformatic analysis repo...

alzheimer's disease (ad) is the most prevalent neurodegenerative disorder. it is characterized by formation of amyloid plaques and neurofibrillary tangles in the brain, degeneration of the cholinergic neurons and neural cell death. this study was aimed to investigate the effect of a triazine derivative, c16h12cl2n3s, on learning in an alzheimer's rat model. animals were divided into seven group...

Neurodegenerative diseases are frequently associated with structural changes in the brain. Magnetic Resonance Imaging (MRI) scans can show these variations and therefore be used as a supportive feature for a number of neurodegenerative diseases. The hippocampus has been known to be a biomarker for Alzheimers disease and other neurological and psychiatric diseases. However, it requires accurate,...